Publications

Research Publications

VanZalen JJ, Harvey S, Hála P, Phillips A, Nakashima T, Gok E, Tiba MH, McCracken BM, Hill JE, Liao J, Jung J, Mergos J, Stacey WC, Bartlett RH, Hsu CH, Rojas-Peña A, Neumar RW. Therapeutic Effect of Argatroban During Cardiopulmonary Resuscitation and Streptokinase During Extracorporeal Cardiopulmonary Resuscitation in a Porcine Model of Prolonged Cardiac Arrest. Crit Care Explor. 2023 May 10;5(5):e0902. doi: 10.1097/CCE.0000000000000902. PMID: 37181541; PMCID: PMC10174369. 

Gottula AL, McCracken BM, Nakashima T, Greer NL, Cramer TA, Sutton NR, Ward KR, Neumar RW, Hakam Tiba M, Hsu CH. Percutaneous left ventricular assist devices in refractory cardiac arrest: The role of chest compressions. Resusc Plus. 2023 Oct 19;16:100488. doi: 10.1016/j.resplu.2023.100488. PMID: 38143529; PMCID: PMC10746849. 

Wider JM, Gruley E, Morse PT, Wan J, Lee I, Anzell AR, Fogo GM, Mathieu J, Hish G, O'Neil B, Neumar RW, Przyklenk K, Hüttemann M, Sanderson TH. Modulation of mitochondrial function with near-infrared light reduces brain injury in a translational model of cardiac arrest. Crit Care. 2023 Dec 14;27(1):491.doi:10.1186/s13054-023-04745-7. PMID: 38098060; PMCID: PMC10720207. 

Nakashima T, Hakam Tiba M, McCracken BM, Hsu CH, Gottula AL, Greer NL, Cramer TA, Sutton NR, Ward KR, Neumar RW. Effect of percutaneous ventricular assisted device on post-cardiac arrest myocardial dysfunction in swine model with prolonged cardiac arrest. Resuscitation. 2023 Dec;193:110010. doi:10.1016/j.resuscitation.2023.110010. Epub 2023 Oct 24. PMID: 37884220. 

Zhang B, McCracken BM, Mahmood CC, Leander D, Greer N, Cranford JA, Hsu CH, Tiba MH, Neumar RW, Greineder CF. Coagulofibrinolytic effects of recombinant soluble thrombomodulin in prolonged porcine cardiac arrest. Resusc Plus. 2023 Sep 27;16:100477. doi: 10.1016/j.resplu.2023.100477. PMID: 37811363; PMCID: PMC10550843. 

Tiba MH, Nakashima T, McCracken BM, Hsu CH, Gottula AL, Greer NL, Cramer TA, Sutton NR, Ward KR, Neumar RW. Haemodynamic impact of aortic balloon occlusion combined with percutaneous left ventricular assist device during cardiopulmonary resuscitation in a swine model of cardiac arrest. Resuscitation. 2023 Aug;189:109885. 

doi: 10.1016/j.resuscitation.2023.109885. Epub 2023 Jun 28. PMID: 37385400. 

Zhang R, Bryson TD, Fogo GM, Liao J, Raghunayakula S, Mathieu J, Wider JM, Ren X, Maheras KJ, Emaus KJ, Gruley E, Chen Y, Neumar RW, Sanderson TH. Rapid Treatment with Intramuscular Magnesium Sulfate During Cardiopulmonary Resuscitation Does Not Provide Neuroprotection Following Cardiac Arrest. Mol Neurobiol. 2022 Mar;59(3):1872-1881. doi: 10.1007/s12035-021-02645-x. Epub 2022 Jan 14. PMID: 35028899; PMCID: PMC8882154. 

Hsu CH, Tiba MH, McCracken BM, Colmenero CI, Pickell Z, Leander DC, Weitzel AM, Raghunayakula S, Liao J, Jinka T, Cummings BC, Pai MP, Alam HB, Ward KR, Sanderson TH, Neumar RW. Dose optimization of early high-dose valproic acid for neuroprotection in a swine cardiac arrest model. Resusc Plus. 2020 Jun 1;1-2:100007. doi: 10.1016/j.resplu.2020.100007. Erratum in: Resusc Plus. 2020 Dec 11;4:100049. PMID: 34223294; PMCID: PMC8244526. 

Anzell AR, Fogo GM, Gurm Z, Raghunayakula S, Wider JM, Maheras KJ, Emaus KJ, Bryson TD, Wang M, Neumar RW, Przyklenk K, Sanderson TH. Mitochondrial fission and mitophagy are independent mechanisms regulating ischemia/reperfusion injury in primary neurons. Cell Death Dis. 2021 May 12;12(5):475. doi: 10.1038/s41419-021-03752-2. PMID: 33980811; PMCID: PMC8115279. 

Fogo GM, Anzell AR, Maheras KJ, Raghunayakula S, Wider JM, Emaus KJ, Bryson TD, Bukowski MJ, Neumar RW, Przyklenk K, Sanderson TH. Machine learning-based classification of mitochondrial morphology in primary neurons and brain. Sci Rep. 2021 Mar 4;11(1):5133. doi: 10.1038/s41598-021-84528-8. PMID: 33664336; PMCID: PMC7933342. 

Hsu CH, Tiba MH, Boehman AL, McCracken BM, Leander DC, Francalancia SC, Pickell Z, Sanderson TH, Ward KR, Neumar RW. Aerosol generation during chest compression and defibrillation in a swine cardiac arrest model. Resuscitation. 2021 Feb;159:28-34. doi: 10.1016/j.resuscitation.2020.12.004. Epub 2020 Dec 15. PMID: 33338570; PMCID: PMC7833865. 

Tiba MH, McCracken BM, Cummings BC, Colmenero CI, Rygalski CJ, Hsu CH, Sanderson TH, Nallamothu BK, Neumar RW, Ward KR. Use of resuscitative balloon 

occlusion of the aorta in a swine model of prolonged cardiac arrest. Resuscitation. 2019 Jul;140:106-112. doi: 10.1016/j.resuscitation.2019.05.010. Epub 2019 May 20. PMID: 31121206; PMCID: PMC7157798. 

Oh JS, Tulasi J, Xiaodan R, Stacey WC, Neumar RW. Valproic Acid Combined With Postcardiac Arrest Hypothermic-Targeted Temperature Management Prevents Delayed Seizures and Improves Survival in a Rat Cardiac Arrest Model. Crit Care Med. 2017 Nov;45(11):e1149-e1156. doi: 10.1097/CCM.0000000000002690. PMID: 28857853. 

Matsuura TR, Bartos JA, Tsangaris A, Shekar KC, Olson MD, Riess ML, Bienengraeber M, Aufderheide TP, Neumar RW, Rees JN, McKnite SH, Dikalova AE, 

Dikalov SI, Douglas HF, Yannopoulos D. Early Effects of Prolonged Cardiac Arrest and Ischemic Postconditioning during Cardiopulmonary Resuscitation on Cardiac 

and Brain Mitochondrial Function in Pigs. Resuscitation. 2017 Jul;116:8-15. doi: 10.1016/j.resuscitation.2017.03.033. Epub 2017 Apr 10. PMID: 28408349; PMCID: 

PMC5552370. 

Kim T, Paine MG, Meng H, Xiaodan R, Cohen J, Jinka T, Zheng H, Cranford JA, Neumar RW. Combined intra- and post-cardiac arrest hypothermic-targeted temperature management in a rat model of asphyxial cardiac arrest improves survival and neurologic outcome compared to either strategy alone. Resuscitation. 2016 Oct;107:94-101. doi: 10.1016/j.resuscitation.2016.07.232. Epub 2016 Aug 10. PMID: 27521473. 

Spinelli E, Davis RP, Ren X, Sheth PS, Tooley TR, Iyengar A, Sowell B, Owens GE, Bocks ML, Jacobs TL, Yang LJ, Stacey WC, Bartlett RH, Rojas-Peña A, Neumar RW. Thrombolytic-Enhanced Extracorporeal Cardiopulmonary Resuscitation After Prolonged Cardiac Arrest. Crit Care Med. 2016 Feb;44(2):e58-69.

 doi: 10.1097/CCM.0000000000001305. PMID: 26488218; PMCID: PMC4948940. 

Bartos JA, Matsuura TR, Sarraf M, Youngquist ST, McKnite SH, Rees JN, Sloper DT, Bates FS, Segal N, Debaty G, Lurie KG, Neumar RW, Metzger JM, Riess ML, Yannopoulos D. Bundled postconditioning therapies improve hemodynamics and neurologic recovery after 17 min of untreated cardiac arrest. Resuscitation. 2015 Feb;87:7-13. doi: 10.1016/j.resuscitation.2014.10.019. Epub 2014 Nov 20. PMID: 25447036; PMCID: PMC4391969. 

Riess ML, Matsuura TR, Bartos JA, Bienengraeber M, Aldakkak M, McKnite SH, Rees JN, Aufderheide TP, Sarraf M, Neumar RW, Yannopoulos D. Anaesthetic 

Postconditioning at the Initiation of CPR Improves Myocardial and Mitochondrial Function in a Pig Model of Prolonged Untreated Ventricular Fibrillation. Resuscitation. 2014 Dec;85(12):1745-51. doi: 10.1016/j.resuscitation.2014.09.019. Epub 2014 Oct 2. PMID: 25281906; PMCID: 

PMC4276313. 

Ma M, Ferguson TA, Schoch KM, Li J, Qian Y, Shofer FS, Saatman KE, Neumar RW. Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration. Neurobiol Dis. 2013 Aug;56:34-46. doi: 10.1016/j.nbd.2013.03.009. Epub 2013 Mar 28. PMID: 23542511; PMCID: PMC3721029. 

Ma M, Shofer FS, Neumar RW. Calpastatin overexpression protects axonal transport in an in vivo model of traumatic axonal injury. J Neurotrauma. 2012 

Nov 1;29(16):2555-63. doi: 10.1089/neu.2012.2473. Epub 2012 Aug 29. PMID: 22776025; PMCID: PMC3495121. 

Kopil CM, Siebert AP, Foskett JK, Neumar RW. Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor impairs ER Ca(2+) buffering and causes neurodegeneration in primary cortical neurons. J Neurochem. 2012 Oct;123(1):147-58. doi: 10.1111/j.1471-4159.2012.07859.x. Epub 2012 Aug 14. PMID: 22762283; PMCID: PMC6718092. 

22: Paine MG, Che D, Li L, Neumar RW. Cerebellar Purkinje cell neurodegeneration after cardiac arrest: effect of therapeutic hypothermia. Resuscitation. 2012 Dec;83(12):1511-6. doi: 10.1016/j.resuscitation.2012.05.022. Epub 2012 Jun 7. PMID: 22683500. 

Ma M, Li L, Wang X, Bull DL, Shofer FS, Meaney DF, Neumar RW. Short-duration treatment with the calpain inhibitor MDL-28170 does not protect axonal transport 

in an in vivo model of traumatic axonal injury. J Neurotrauma. 2012 Jan 20;29(2):445-51. doi: 10.1089/neu.2011.2060. Epub 2012 Jan 6. PMID: 22077394; PMCID: PMC3261786. 

Kopil CM, Vais H, Cheung KH, Siebert AP, Mak DD, Foskett JK, Neumar RW. Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) has InsP(3)-independent gating and disrupts intracellular Ca(2+) homeostasis. J Biol Chem. 2011 Oct 14;286(41):35998-36010. doi: 10.1074/jbc.M111.254177. Epub 2011 Aug 22. PMID: 21859719; PMCID: PMC3195633. 

Che D, Li L, Kopil CM, Liu Z, Guo W, Neumar RW. Impact of therapeutic hypothermia onset and duration on survival, neurologic function, and neurodegeneration after cardiac arrest. Crit Care Med. 2011 Jun;39(6):1423-30. doi: 10.1097/CCM.0b013e318212020a. PMID: 21610611; PMCID: PMC3102228. 

Bevers MB, Ingleton LP, Che D, Cole JT, Li L, Da T, Kopil CM, Cohen AS, Neumar RW. RNAi targeting micro-calpain increases neuron survival and preserves hippocampal function after global brain ischemia. Exp Neurol. 2010 Jul;224(1):170-7. doi: 10.1016/j.expneurol.2010.03.007. Epub 2010 Mar 15. PMID:20298691; PMCID: PMC2885584.

Bevers MB, Lawrence E, Maronski M, Starr N, Amesquita M, Neumar RW. Knockdown of m-calpain increases survival of primary hippocampal neurons following NMDA excitotoxicity. J Neurochem. 2009 Mar;108(5):1237-50. doi:

10.1111/j.1471-4159.2008.05860.x. Epub 2009 Jan 22. PMID: 19141074; PMCID: PMC2676331.

Frederick JR, Chen Z, Bevers MB, Ingleton LP, Ma M, Neumar RW. Neuroprotection with delayed calpain inhibition after transient forebrain ischemia. Crit Care Med. 2008 Nov;36(11 Suppl):S481-5. doi: 10.1097/ccm.0b013e31818a8ec8. PMID: 20449914; PMCID: PMC2867247.

Bevers MB, Neumar RW. Mechanistic role of calpains in postischemic neurodegeneration. J Cereb Blood Flow Metab. 2008 Apr;28(4):655-73. doi: 10.1038/sj.jcbfm.9600595. Epub 2007 Dec 12. PMID: 18073773.